FACTS ABOUT PKRRATING REVEALED

The interfacial residues are extremely conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements show the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations help a design the place activating RNA serves to be a scaffold to bind numerous PKR monomers, increasing the re

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